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孕早期血清载脂蛋白水平对晚发型先兆子痫预测作用的研究

朱 娟娟, 刘 烨, 黄 杭珍

摘要

目的 探讨孕早期血清载脂蛋白A1(ApoA1)和载脂蛋白B(ApoB)水平对晚发型先兆子痫的预测价值。方法 前瞻性选取2024年1-12月在我院建卡分娩的200例单胎孕妇,根据妊娠结局分为晚发型先兆子痫组和正常对照组各100例。孕6-12周检测血清ApoA1、ApoB水平,分析其预测价值。结果 先兆子痫组ApoB(1.35±0.28g/L)高于对照组(0.89±0.20g/L),ApoA1(1.16±0.23g/L)低于对照组(1.48±0.29g/L),P<0.001。ROC曲线显示ApoB/ApoA1比值AUC=0.851,敏感度78%,特异度76%。Logistic回归显示ApoB≥1.10g/L(OR=3.15)、ApoA1<1.30g/L(OR=2.32)是独立危险因素。结论 孕早期载脂蛋白可有效预测晚发型先兆子痫,建议纳入常规筛查。

关键词

载脂蛋白B, 载脂蛋白A1, 晚发型先兆子痫, 预测, 前瞻性研究

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参考

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